TiCl4/Et3N-Promoted Three-Component Condensation between Aromatic Heterocycles, Aldehydes, and Active Methylene Compounds

Renzetti, Andrea; Dardennes, Emmanuel; Fontana, Antonella; Maria, Paolo De; Sapi, Janos; Gérard, Stéphane

doi:10.1021/jo800529q.s001

jo800529q_si_001.pdf (5.84 MB)

TiCl₄/Et₃N-Promoted Three-Component Condensation between Aromatic Heterocycles, Aldehydes, and Active Methylene Compounds

journal contribution

posted on 2008-09-05, 00:00 authored by Andrea Renzetti, Emmanuel Dardennes, Antonella Fontana, Paolo De Maria, Janos Sapi, Stéphane Gérard

A one-pot methodology for the synthesis of polyfunctionalized indole derivatives by a TiCl₄/Et₃N-promoted trimolecular condensation of aldehydes, indole heterocycles, and various activated carbonyl compounds is reported. Rationalization of these reactions and extension to other heterocyclic systems is also described.