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Three optimal cut-point selection criteria based on sensitivity and specificity with user-defined weights

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posted on 2018-02-27, 14:32 authored by Dan-Ling Li, Jun-Xiang Peng, Chong-Yang Duan, Ju-Min Deng

Methods: Based on the index S (S = SENSITIVITY (SEN) × SPECIFICITY (SPE)), the new weighted product index Sw is defined as Sw = (SEN)2w × (SPE)2(1-w), where (0≤w≤1). The Sw is developed to be a new tool to select the optimal cut point in ROC analysis and be compared with the other two commonly used criteria.

Results: Comparing the optimal cut point for the three criteria, the wave range of the optimal cut point for the maximized weighted Youden index criterion is the widest, the weighted closest-to-(0,1) criterion is the narrowest and the weighted product index Sw criterion lays between the ranges of the two criteria.

Funding

National Nature Science Foundation of China [81402759]; Natural Science Foundation of Guangdong Province [2015A030310279]; and Science and technology development, Southern Medical University [KJ20161126].

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