Three-dimensional surface plot showing the main effects for a multiple regression of total Ratingen score versus duration of disease and number of 1G()-5A() haplotypes
Taken from "Association of a specific haplotype across the genes and with radiographic joint destruction in rheumatoid arthritis"
Arthritis Research & Therapy 2004;6(3):R199-R207.
Published online 8 Mar 2004
Copyright © 2004 Dörr et al., licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.The plot was created by distance-weighted least-squares interpolation. Black lines represent patients with either none or two 1G-5A haplotypes. The broken line, representing patients with one haplotype, is an approximation because it was not possible to determine exactly the number of patients with one 1G-5A haplotype. The arrow indicates the maximum increase in the Ratingen score after 15 years of rheumatoid arthritis in patients with no 1G-5A haplotype (see the text for further explanations). MMP, matrix metalloproteinase.