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Three-dimensional polycaprolactone-bioactive glass composite scaffolds: Effect of particle size and volume fraction on mechanical properties and in vitro cellular behavior

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posted on 2018-01-16, 15:37 authored by Elnaz Tamjid

In this study, highly porous polycaprolactone-based composites (90% porosity) with hierarchical pore structure (400–500 µm) and nanotopographical features were prepared by 3D printing. 45S5 Bioglass particles with different sizes (<100 nm; 250 nm; 6 µm) and concentrations (2, 6, and 10 vol%) were utilized to attain improved mechanical strength and bioactivity. The micrometric particles embedded in the polymer matrix enhanced the elastic modules up to 235%. The ultrafine particles decorated the struts and affected nanotopography, hydrophilicity, and nanohardness by about 100%. The rate of pore filing lowers in the presence of nanoparticles as compared with microparticles.

Funding

The author would like to acknowledge the Deputy Office for Research and Technology of Tabriat Modares University for providing facilities and financial support.

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