gnpl_a_1224867_sm1127.pdf (1.23 MB)
The structure proposed for apteniol D is different from that of the compound obtained by total synthesis
journal contribution
posted on 2016-08-26, 07:08 authored by Toshiro Noshita, Kohei Matsumoto, Hikaru Nishikawa, Hidekazu Ouchi, Yoshitomo Hamada, Akiko Saito, Teiko YamadaWe describe the synthesis of 4,4′-oxyneolignan, the proposed structure for naturally occurring apteniol D. The diphenyl ether moiety in 4,4′-oxyneolignan was formed via classical Ullmann ether synthesis using excess copper powder in N,N-dimethylacetamide. The spectral data of synthesised apteniol D show differences compared to those of naturally occurring apteniol D.