The role of vascular NADPH oxidase enzymes in influenza morbidity

Every year, up to half a million people lose their lives to influenza infection. Australia recently experienced the worst seasonal influenza epidemic since the 2009 Swine Flu pandemic. The hallmarks of serious cases of influenza infections include an exaggerated inflammatory response, oxidative stress, heart problems, and lung damage. This thesis explores how the cells lining the blood vessels, the endothelium, contributes to these issues. In particular, it examines the role of the NADPH oxidases; a source of oxidants. The pathways examined in this thesis provide a deeper understanding of influenza pathology that could lead to more innovative and beneficial treatments.