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The regulatory network of ncRNAs and mRNAs in workers exposed to MWCNTs.

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posted on 2016-03-01, 06:59 authored by Anna A. Shvedova, Naveena Yanamala, Elena R. Kisin, Timur O. Khailullin, M. Eileen Birch, Liliya M. Fatkhutdinova

The regulatory networks of significantly dysregulated lncRNAs and mRNAs (p-value<0.05, fold-change>±1.5) having positional and/or functional relationship with (A) up-regulated miRNAs (p<0.05, fold-change>1.5) and (B) down-regulated miRNAs (p>0.05, fold-change>-1.5), generated using IPA. The lncRNAs, represented using red (↓) and green (↑) rectangles and dotted lines, with consistent co-expression as mRNAs and/or containing miRNA target binding sites from starBase v2.0 were manually added to the network.

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