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The proposed mechanism for the bioactivation of Erlotinib by P450s.

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posted on 2017-06-19, 17:37 authored by Chun-Zhi Ai, Yong Liu, Wei Li, De-Meng Chen, Xin-Xing Zhu, Ya-Wei Yan, Du-Chu Chen, Yi-Zhou Jiang

The proposed mechanism for the bioactivation of Erlotinib by P450s.

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    quinine-imineCytochrome P 450soxidative reaction pathwaybarrierside-onDFTP 450scytochrome P 450sreactive electrophilesreactive electrophile bioactivatedmechanismbioactivationErlotinib EGFR inhibitors

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