The <i>CELSR1</i> polymorphisms rs6007897 and rs4044210 are associated with ischaemic stroke in Chinese Han population

<p><i>Background</i>: Recently, CELSR1 was identified by genome-wide association studies (GWAS) as a susceptibility gene for ischaemic stroke (IS) in Japanese individuals.</p> <p><i>Aim</i>: The goal was to examine whether CELSR1 variants are associated with IS in the Chinese Han population.</p> <p><i>Subjects and methods</i>: This study genotyped two single nucleotide polymorphisms (SNPs) of CELSR1, rs6007897 and rs4044210, in a Chinese sample of 569 IS cases and 581 controls and assessed their genotype and allele associations with IS.</p> <p><i>Results</i>: The results showed that rs6007897 and rs4044210 variants of CELSR1 were significantly (<i>p</i> < 0.01) associated with IS. These associations remained after adjustment for age, gender, smoking status, hypertension, diabetes mellitus and hypercholesterolemia. In addition, a significant association was observed of rs6007897 and rs4044210 of CELSR1 with large artery atherosclerosis (LAA), a sub-type of IS (<i>p</i> < 0.01).</p> <p><i>Conclusion</i>: Taken together, the present study has proven for the first time that CELSR1 is a susceptibility gene for IS in the Chinese Han population, especially for LAA.</p>