The hypoglycemic and antioxidant activities of garden cress (<i>Lepidium sativum</i> L.) seed on alloxan-induced diabetic male rats

<p>The hypoglycemic and antioxidants activities of the methanol extract of <i>Lepidium sativum</i> seeds was tested in alloxan-induced diabetic male rats. Thirty male <i>albino</i> rats weighing 190–200 g were divided into five groups as follows: negative control, positive control and three diabetic groups treated with three concentrations of <i>L. sativum</i> methanol extract for four weeks. Induction of hyperglycemia in the positive control group increased blood glucose, glycated hemoglobin A1c, immunoglobulins, liver enzyme, lipid peroxide and kidney function, total cholesterol, low-density lipoproteins, very low-density lipoproteins and decreased antioxidants and high-density lipoproteins compared with the negative control. Furthermore, pancreas tissues showed pathological changes compared with the negative control. Treating the diabetic rats with <i>L. sativum</i> methanol extract decreased blood sugar and restored all biochemical and histological changes to the normal. It could be concluded that <i>L. sativum</i> methanol extract succeeded in controlling diabetes, increasing antioxidants and ameliorating lipid profile.</p>