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The function of BCL9 in Wnt/β-catenin signaling and colorectal cancer cells-5

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posted on 2011-12-31, 20:02 authored by Marc de la Roche, Jesper Worm, Mariann Bienz
numbers in the latter two refer to mouse or human HD2 sequences, which are identical). Individual conserved residues () were mutated, and semiquantitative estimates of their binding affinities (++/+/-) to the β-catenin ARD are given underneath. , pull-down assays between translated wt and mutant BCL9 HD2 and GST-ARD, as indicated; input lanes, 5% of the total binding reaction. , co-immunoprecipitations of FLAG-tagged wt and mutant BCL9 or BCL9-2 with HA-β-catenin expressed in HEK 293T cells; , protein expression levels in the lysates.

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Taken from "The function of BCL9 in Wnt/β-catenin signaling and colorectal cancer cells"

http://www.biomedcentral.com/1471-2407/8/199

BMC Cancer 2008;8():199-199.

Published online 15 Jul 2008

PMCID:PMC2478683.

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