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The effect of lithium on blood glucose and insulin levels.
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posted on 2017-12-15, 18:40 authored by Theun de Groot, Lars Damen, Leanne Kosse, Mohammad Alsady, Rosalinda Doty, Ruben Baumgarten, Susan Sheehan, Johan van der Vlag, Ron Korstanje, Peter M. T. Deen12-week old female BTBR-WT and -ob/ob mice received standard chow or chow with lithium supplementation (10 or 40 mmol LiCl/kg) for 12 weeks. Two weeks before sacrifice, mice were fasted for 4 hours, after which they received an intraperitoneal injection of 2 mg glucose/g bodyweight. Blood was collected before and 15 minutes after injection and blood glucose levels were determined (A). At the time of sacrifice blood was collected to analyze non-fasting (B) glucose and (C) insulin levels, n = 9 per group. *p<0.05; **p<0.01; ***p<0.001.
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GSK 3 inhibition increases glucose uptakeblood lithium levelsdiabetes mellitusNGALblood glucose levelsnephropathyLi -40 dietGSK 3 inhibitionGSK 3 inhibitorimmunoglobulin G levelslithium attenuates non-fasting blood glucose levelsalbuminBTBR-WTtubule brush borderglomerulosclerosiBTBRnon-fasting blood glucose levelsimmunoglobulin G contentkidney injury
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