The Pediatric Template of Brain Perfusion (PTBP)

2015-02-04T16:18:17Z (GMT) by Brian Avants ntustison Danny JJ Wang

Magnetic resonance imaging (MRI) captures the dynamics of brain development with high spatial resolu- tion and with complementary modalities that quantify both brain structure and function. These measurements may yield valuable insights into the neural patterns that mark healthy maturation or that identify early risk for psychiatric disorder later in life. The Pediatric Template of Brain Perfusion (PTBP) is a free and public neuroimaging resource that will help accelerate the understanding of childhood brain development as seen through the lens of multiple modality neuroimaging and in relation to cognitive and environmental factors. The PTBP uses MRI to quantify cortex (T1), white matter (DTI), resting state functional connectivity (BOLD) and brain perfusion, as measured by Arterial Spin Labeling (ASL), in >100 children 7—17 years of age. The PTBP captures, within normally developing children and across several modalities, the trajectories that demarcate critical turning points in brain maturation. This novel resource allows a more detailed understanding of the structural and functional landmarks that are obtained during normal adolescent brain development.  The full raw nifti dataset is available at the link below.

The file  jjperf.Rnw is the original knitr version of the article - no guarantee to compile "out of the box" nor to be consistent with the official final version of the manuscript which underwent revision outside of the knitr world.   There are also several typos in this version.

The PTBP was supported by Danny JJ Wang's R01MH080892 funded by NIMH.  The article is in press.