jo6b00710_si_001.pdf (3.62 MB)
The Formation of Seven-Membered Heterocycles under Mild Pictet–Spengler Conditions: A Route to Pyrazolo[3,4]benzodiazepines
journal contribution
posted on 2016-05-09, 00:00 authored by Timothy
A. Katte, Tristan A. Reekie, William T. Jorgensen, Michael KassiouReported
is a method for the synthesis of seven-membered heterocycles
via a Pictet–Spengler condensation reaction under very mild
conditions. High substrate scope allows for use of aldehydes using
catalytic amounts of acetic acid yielding 39–90% and ketones
using catalytic amounts of trifluoroacetic acid yielding 25–83%.