ol6b00018_si_004.cif (1.91 MB)
Tandem Radical Fluoroalkylation–Cyclization: Synthesis of Tetrafluoro Imidazopyridines
dataset
posted on 2016-01-28, 00:00 authored by Julie Charpentier, Natalja Früh, Simon Foser, Antonio TogniA copper-catalyzed
fluoroalkylation–cyclization sequence
of alkenes and alkynes enables the synthesis of fluorinated tetra-
and dihydroimidazopyridines in moderate to excellent yields
within 1 h at 70 °C. This reaction, which is carried out using
copper(I) acetate as the catalyst, makes use of a new class of functionalized
tetrafluoroethyl reagents based on a hypervalent iodine scaffold.