Tandem Palladium-Catalyzed Addition/Cyclocarbonylation: An Efficient Synthesis of 2-Heteroquinazolin-4(<i>3H</i>)-ones

2010-03-19T00:00:00Z (GMT) by Fanlong Zeng Howard Alper
A highly practical and efficient method for the synthesis of 2-heteroquinazolin-4(<i>3H</i>)-ones has been developed by a palladium-catalyzed tandem reaction. Under mild reaction conditions (80 °C, 100 psi), a wide variety of 2-heteroquinazolin-4(3<i>H</i>)-ones were obtained in good to excellent yields.