Tandem Palladium-Catalyzed Addition/Cyclocarbonylation: An Efficient Synthesis of 2-Heteroquinazolin-4(3H)-ones

A highly practical and efficient method for the synthesis of 2-heteroquinazolin-4(3H)-ones has been developed by a palladium-catalyzed tandem reaction. Under mild reaction conditions (80 °C, 100 psi), a wide variety of 2-heteroquinazolin-4(3H)-ones were obtained in good to excellent yields.