Table S1; Fig. S1; Appendix S1; Figure S2; Figure S3; Figure S4 from Dodging silver bullets: good CRISPR gene-drive design is critical for eradicating exotic vertebrates.

Demographic parameters used for the stochastic individual-based model.; Diagram of the individual-based model structure and flow.; R function to calculate transition probabilities (P_sj) for germline homing, assuming simultaneous expression of multiplexed gRNAs.; Impact of reproductive compensation on the homozygotic embryonic non-viability strategy.; Probability of successful homing under sequential and simultaneous gRNA expression.; Mean time to simulated eradication for different pest species.