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Synthesis of quinoline based [1,2,4]-dithiazolidines through sulfur-sulfur bond formation and their evaluation as anti-inflammatory and antibacterial agents

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journal contribution
posted on 2016-02-06, 21:42 authored by Spruha A. Gharad, Baliram N. Berad, Snehal A. Chavan

A series of [1,2,4]-dithiazolidines carrying the quinoline moiety has been synthesized. 2-Chloroquinolin-3-carbaldehyde reacted with various 4-arylthiosemicarbazides to form the corresponding 1-[(2-chloroquinolin-3-yl)methylene]-4-arylthiosemicarbazides. The synthesis of 3,5-(diarylimino)-4[(2-chloroquinolin-3-yl)methyleneamino]-[1,2,4]-dithiazolidines was achieved by the interaction of 1-[(2-chloroquinolin-3-yl)methylene]-4-arylthiosemicarbazides with N-aryl-S-chloroisothiocarbamoyl chlorides through S–S and C–N bond formations. The structures of newly synthesized compounds were confirmed on the basis of IR, 1H & 13C NMR and Mass spectral data. The title compounds were screened for their anti-inflammatory and antibacterial activities.

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