Synthesis of new water soluble diorganotin(IV) complexes with hydrazones derived from Girard-T reagent as antibacterial and anticancer agents

<p>Three new water-soluble organotin complexes R<sub>2</sub>Sn(5-BrSalGT)Cl [R = Ph, Me] and Ph<sub>2</sub>Sn(2-OHNaphGT)Cl have been synthesized by the reaction of R<sub>2</sub>SnCl<sub>2</sub> (R = Ph or Me) with Schiff bases derived from condensation of Girard-T reagent with 5-bromosalicylaldehyde and 2-naphthaldehyde, (5-BrH<sub>2</sub>SalGT)Cl (<b>1</b>) and (2-OHH<sub>2</sub>NaphGT)Cl (<b>2</b>). The synthesized compounds have been investigated by elemental analysis, conductometric measurements, IR, <sup>1</sup>H NMR, and <sup>119</sup>Sn NMR spectroscopy. These data show that the deporotonated ligand is coordinated to Sn(IV) via ONO atoms and six-coordinate zwitterionic complexes are formed. The ligands and their complexes were investigated for their <i>in vitro</i> toxicity against Gram-positive (<i>Bacillus subtilis</i> and <i>Staphylococcus aureus</i>) and Gram-negative (<i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i>) bacteria. The results show remarkable antibacterial activity against the studied bacteria. All complexes exhibit more inhibitory effects than the parent ligand. The anticancer activity of all compounds were also performed on HN5 cell line and (2-OHH<sub>2</sub>NaphGT)Cl with concentration of 1 mg mL<sup>−1</sup> was found to show higher anticancer activity than other compounds.</p>