tgcl_a_1510991_sm3504.docx (1.33 MB)
Synthesis of bioactive heterocycles using reusable heterogeneous catalyst HClO4–SiO2 under solvent-free conditions
journal contribution
posted on 2018-08-21, 13:46 authored by Leimajam Vartima Chanu, Thokchom Prasanta Singh, Laishram Ronibala Devi, Okram Mukherjee SinghWe are reporting a simple, efficient and green protocol for the synthesis of chromenes and dihydropyrimidines (products of Knoevenagel and Biginelli reaction, respectively) by the use of silica-supported perchloric acid (HClO4–SiO2) as an effective heterogeneous catalyst. Short reaction times, high product yields, simple procedure and reusability of the catalyst are the superior characteristics of this protocol.