Synthesis of a Gln-Phe Hydroxy-ethylene Dipeptide Isostere

2004-12-09T00:00:00Z (GMT) by Bengt Erik Haug Daniel H. Rich
The protected Gln-Phe hydroxyethylene dipeptide isostere <b>1</b> was synthesized as a precursor for preparation of potential inhibitors of Botulinum neurotoxin B metalloprotease. The method allows for the synthesis of additional hydroxyethylene dipeptide isosteres such as <b>2</b> with functionalized P<sub>1</sub> side chains. The isosteres prepared were coupled with a dipeptide to produce protected pseudotetrapeptide derivatives.