Synthesis of thienyl-substituted isochromene derivatives through gold-catalyzed tandem heteroarylation/cycloisomerization of <i>ortho</i>-alkynylbenzaldehydes with thiophenes

<p>We describe herein a gold-catalyzed tandem heteroarylation/cycloisomerization reaction of <i>ortho</i>-alkynylbenzaldehydes with thiophenes. By this reaction, a variety of 1-(thiophen-2-yl)-1<i>H</i>-isochromene derivatives can be obtained in good yield.</p>