Synthesis of pyridazinones via molecular-iodine-mediated cleavage of 4-bromomethylcoumarin precursors

Shamala, Devadas; Shivashankar, Kalegowda

doi:10.6084/m9.figshare.3753237.v2

lsyc_a_1223310_sm1948.docx (2.68 MB)

Synthesis of pyridazinones via molecular-iodine-mediated cleavage of 4-bromomethylcoumarin precursors

Version 2 2016-10-08, 04:54

Version 1 2016-08-23, 20:00

journal contribution

posted on 2016-10-08, 04:54 authored by Devadas Shamala, Kalegowda Shivashankar

A facile and an efficient protocol for the synthesis of pyridazinones via molecular-iodine-mediated cleavage of 4-bromomethylcoumarin precursors in the presence of I₂ in ethanol at 70 °C is reported. The present approach replaced the basic condition (K₂CO₃) with Lewis acidic condition.