Synthesis of Luffarin L and 16-<i>epi</i>-Luffarin L Using a Temporary Silicon-Tethered Ring-Closing Metathesis Reaction

The first synthesis of luffarin L (<b>1</b>) and 16-<i>epi</i>-luffarin L (<b>2</b>) by a silicon-tethered ring closing metathesis as a key step has been achieved. The stereochemistry and absolute configuration of the natural sesterterpenolide luffarin L (<b>1</b>) and a new route for the stereoselective synthesis of sesterterpenolides with a luffarane skeleton have been established.