jo5b00876_si_001.pdf (4.79 MB)
Synthesis of Luffarin L and 16-epi-Luffarin L Using a Temporary Silicon-Tethered Ring-Closing Metathesis Reaction
journal contribution
posted on 2015-06-19, 00:00 authored by Aitor Urosa, Isidro
S. Marcos, David Díez, José M. Padrón, Pilar BasabeThe
first synthesis of luffarin L (1) and 16-epi-luffarin L (2) by a silicon-tethered ring
closing metathesis as a key step has been achieved. The stereochemistry
and absolute configuration of the natural sesterterpenolide luffarin
L (1) and a new route for the stereoselective synthesis
of sesterterpenolides with a luffarane skeleton have been established.