om9b00447_si_002.xyz (9.42 kB)
Synthesis of Ferrocenyl Alkyne–Cu(I) π‑Complexes via Copper-Promoted 8‑Aminoquinoline-Directed C–H Bond Alkynylations
dataset
posted on 2019-08-23, 20:13 authored by Zenan Song, Yongqi Yu, Lin Yu, Da Liu, Qianlong Wu, Zhen Xia, Yuanjiu Xiao, Ze TanA highly monoselective synthesis
of ferrocenyl alkynes was achieved
via Cu-promoted ferrocene C(sp2)–H bond activations.
The reaction employs an 8-aminoquinoline group as the directing group
and terminal alkynes as the alkyne source. It was found the alkynylation
products actually complex with the in situ generated Cu(I) ions to
give robust and stable alkyne π-copper complexes. In addition,
these alkyne π-copper complexes could be freed of the copper
ions to give various ferrocenyl alkynes in almost quantitative yields.
The test results also showed that the alkyne π-copper complexes
could be reformed from the free alkynes upon treating them with Cu(I)
salts.