ol005800t_si_001.pdf (42.12 kB)
Synthesis of Enamides Related to the Salicylate Antitumor Macrolides Using Copper-Mediated Vinylic Substitution
journal contribution
posted on 2000-04-05, 00:00 authored by Ruichao Shen, John A. PorcoA new approach to the assembly of enamides is described using copper(I) carboxylate-catalyzed substitution of vinyl iodides and amides.
Modified reaction conditions have been developed to synthesize the O-methyloxime enamide side chains related to the natural products
lobatamides A−F, oximidine I and II, and CJ-12 950.