jo050798a_si_001.pdf (1.69 MB)
Synthesis of Crescent Aromatic Oligoamides
journal contribution
posted on 2005-12-23, 00:00 authored by Lihua Yuan, Adam R. Sanford, Wen Feng, Aimin Zhang, Jin Zhu, Huaqiang Zeng, Kazuhiro Yamato, Minfeng Li, Joseph S. Ferguson, Bing GongThis article describes the synthetic procedures for the preparation of crescent (and helical) aromatic
oligoamides developed in recent years in our laboratory. The large-scale preparation of a variety of
monomers derived from various tetrasubstituted benzenes is presented. Three different strategies
for constructing various oligomers consisting of meta- and meta/para-linked benzene residues are
discussed. Factors affecting coupling efficiency and yields are analyzed. The developed synthetic
methods have provided the basis for the preparation of longer oligomers and for the development
of solid-phase synthesis.