Synthesis of Benzisoxazoles by the [3 + 2] Cycloaddition of <i>in situ</i> Generated Nitrile Oxides and Arynes

2010-03-19T00:00:00Z (GMT) by Anton V. Dubrovskiy Richard C. Larock
A variety of substituted benzisoxazoles has been prepared by the [3 + 2] cycloaddition of nitrile oxides and arynes. Both components, being highly reactive intermediates, have been generated <i>in situ</i> by fluoride anion from readily prepared aryne precursors and chlorooximes. The reaction scope is quite general, affording a novel, direct route to functionalized benzisoxazoles under mild reaction conditions.