Synthesis
of Antioxidants for Prevention of Age-Related
Macular Degeneration

Joshi, Dharati; Field, James; Murphy, John; Abdelrahim, Mohammed; Schönherr, Heike; Sparrow, Janet R.; Ellestad, George; Nakanishi, Koji; Zask, Arie

doi:10.1021/np300769c.s001

np300769c_si_001.pdf (609.62 kB)

Synthesis of Antioxidants for Prevention of Age-Related Macular Degeneration

journal contribution

posted on 2013-03-22, 00:00 authored by Dharati Joshi, James Field, John Murphy, Mohammed Abdelrahim, Heike Schönherr, Janet R. Sparrow, George Ellestad, Koji Nakanishi, Arie Zask

Photooxidation of A2E may be involved in diseases of the macula, and antioxidants could serve as therapeutic agents for these diseases. Inhibitors of A2E photooxidation were prepared by Mannich reaction of the antioxidant quercetin. These compounds contain water-solubilizing amine groups, and several were more potent inhibitors of A2E photooxidation than quercetin.