ao7b00383_si_001.pdf (2.97 MB)
Synthesis of 3‑CF2‑Containing Chromones via a Visible-Light-Induced Radical Cascade Reaction of o‑Hydroxyaryl Enaminones
journal contribution
posted on 2017-07-05, 17:18 authored by Huang Gao, Bei Hu, Wuheng Dong, Xiaoshuang Gao, Lili Jiang, Xiaomin Xie, Zhaoguo ZhangA general and efficient
visible-light-induced CF2 radical-based
cascade reaction of o-hydroxyaryl enaminones has
been described. This protocol afforded the corresponding functionalized
3-CF2-containing chromones in generally good yields under
mild reaction conditions. The use of NaHSO3, which has
both basicity and reducibility, efficiently suppressed the formation
of two byproducts, 4H-chromen-4-one and 3-bromo-4H-chromen-4-one.