gpss_a_798790_sm4852.doc (296.23 kB)
Synthesis of 3-(3-(Phenacyl/Alkyl/Benzylthio)-[1,2,4]Triazolo[3,4-B][1,3,4]Thiadiazol-6-Yl)-2H-Chromen-2-Ones
journal contribution
posted on 2014-01-01, 00:00 authored by Rajeswar Rao Vedula, Sreenu PavuralaReaction of coumarin-3-carboxylic acid with 3,5-di mercapto-4-amino-s-triazole in POCl3to generate 3-(3-mercapto-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl)-2H-chromen-2-one (3). Reaction of 3 with different substituted phenacyl/benzyl/allyl bromides in anhydrous ethanol gave corresponding 3-(3-(phenacyl/alkyl/benzylthio)-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazol-6-yl)-2H-chromen-2-ones 5. The structures of newly prepared compounds were confirmed by their analytic and spectral data.