jo202663n_si_001.pdf (3.36 MB)
Synthesis of 2,5-Disubstituted Oxazoles and Oxazolines Catalyzed by Ruthenium(II) Porphyrin and Simple Copper Salts
journal contribution
posted on 2016-02-21, 12:33 authored by Chuan
Long Zhong, Bo Yang Tang, Ping Yin, Yue Chen, Ling HeA novel and moderate synthesis of 2,5-disubstituted oxazoles
and
oxazolines involving ruthenium(II) porphyrin–copper chloride
catalyzed cyclization was developed. These reactions using readily
available benzene carboxylic acids and phenylethenes or phenylacetylenes
are performed under mild conditions. The reactions proceed in series,
giving rise to the formation of an intermolecular C–N bond
and an intramolecular C–O bond, which yield oxazole or oxazoline
derivatives simultaneously.