ol6b01521_si_001.pdf (3.16 MB)
Synthesis of 1‑Substituted Isoquinolines by Heterocyclization of TosMIC Derivatives: Total Synthesis of Cassiarin A
journal contribution
posted on 2016-06-28, 16:05 authored by Sara Gutiérrez, Anna Coppola, David Sucunza, Carolina Burgos, Juan J. VaqueroA new
method for the synthesis of 1-substituted isoquinolines by
a heterocyclization that involves α-benzyl TosMIC derivatives
and different electrophiles has been developed. This methodology has
been successfully applied to a total synthesis of cassiarin A, an
alkaloid with potent antiplasmodial activity against Plasmodium
falciparum.