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Synthesis of 1‑Substituted Isoquinolines by Heterocyclization of TosMIC Derivatives: Total Synthesis of Cassiarin A

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posted on 2016-06-28, 16:05 authored by Sara Gutiérrez, Anna Coppola, David Sucunza, Carolina Burgos, Juan J. Vaquero
A new method for the synthesis of 1-substituted isoquinolines by a heterocyclization that involves α-benzyl TosMIC derivatives and different electrophiles has been developed. This methodology has been successfully applied to a total synthesis of cassiarin A, an alkaloid with potent antiplasmodial activity against Plasmodium falciparum.

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