Synthesis of [1,2,3]Triazolo[5,1-<b><i>a</i></b>]isoquinoline Derivatives via a Selective Cascade Cyclization Sequence of 1,2-bis(Phenylethynyl)benzene Derivatives

<div><p></p><p>A direct, concise, synthetic method for the generation of [1,2,3]triazolo[5,1-<i>a</i>]isoquinoline derivatives, using a selective cascade cyclization of unsymmetrical substituted 1,2-bis(phenylethynyl)benzene derivatives with NaN<sub>3</sub>, has been developed. The reaction gave different substituted [1,2,3]triazolo[5,1-<i>a</i>]isoquinolines in moderate to good yields. It was found that the substituents on the alkynes were important for the selectivities of the cascade cyclization sequences.</p></div>