lsyc_a_1428816_sm8641.pdf (3.19 MB)
Synthesis of α-arylalkylferrocenes through cesium fluoride-promoted coupling of arylboronic acids with N-tosylhydrazones
journal contribution
posted on 2018-03-09, 15:27 authored by Yueqiang Liu, Xiaowei Ma, Yan Liu, Ping Liu, Bin DaiA cesium fluoride-promoted reductive coupling reaction of acylferrocene tosylhydrazones with arylboronic acids has been developed, producing highly substituted α-arylalkylferrocenes in moderate to excellent yields. The reaction employs anionic fluorine to facilitate the cleavage of C–B bond. The developed methodology demonstrates a wide substrate scope and high functional groups tolerance. Moreover, the α-arylalkylferrocenes compounds were also obtained on a multi-gram scale.