Synthesis and <i>in vitro</i> antiproliferative and antibacterial activity of new thiazolidine-2,4-dione derivatives

<p>In our present research, we synthesised new thiazolidine-2,4-diones (<b>12–28</b>). All the newly synthesised compounds were evaluated for antiproliferative and antibacterial activity. Antiproliferative evaluation was carried out using normal human skin fibroblasts and tumour cell lines: A549, HepG2, and MCF-7. The IC<sub>50</sub> values were determined for tested compounds revealing antiproliferative activity. Moreover, safety index (SI) was calculated. Among all tested derivatives, the compound <b>18</b> revealed the highest antiproliferative activity against human lung, breast, and liver cancer cells. More importantly, the derivative <b>18</b> showed meaningfully lower IC<sub>50</sub> values when compared to the reference substance, irinotecan, and relatively high SI values. Moreover, newly synthesised compounds were screened for the bacteria growth inhibition <i>in vitro.</i> According to our screening results, most active compound was the derivative <b>18</b> against Gram-positive bacteria. Therefore, it may be implied that the novel compound <b>18</b> appears to be a very promising agent for anticancer treatment.</p>