Synthesis and biological evaluation of stilbene derivatives coupled to NO donors as potential antidiabetic agents

<p>The work is focused on the design of drugs that prevent and treat diabetes and its complications. A novel class of stilbene derivatives were prepared by coupling NO donors of alkyl nitrate and were fully characterised by NMR and other techniques. These compounds were tested <i>in vitro</i> activity, including α-glucosidase inhibitory activity, aldose reductase (AR) inhibitory activity and advanced glycation end products (AGEs) formation inhibitory activity. A class of modified compounds could play a significant effect for treatment of diabetic complications. Target compounds <b>3e</b> and <b>7c</b> offered a potential drug design concept for the development of therapeutic or preventive agents for diabetes and its complications.</p>