Synthesis and Characterization of Unsymmetric 4-Picolyl Selenides

<p>A number of unsymmetrical heteroaryl 4-picolyl selenides have been prepared by lithiation of 4-picoline using lithium diisopropylamide under cryogenic conditions. The intermediate 4-lithiopicoline formed was then reacted with elemental selenium followed by the addition of suitable electrophiles to give 4-picolyl alkyl selenides. 4-Lithiopicoline was also made to react directly with diaryl/dibenzyl diselenide to yield mixed 4-picolyl aryl/benzyl selenides. All these hitherto unknown selenides were characterized through various spectroscopic techniques viz., NMR (<sup>1</sup>H, <sup>13</sup>C, <sup>77</sup>Se), IR and mass spectrometry.</p>