Synthesis and Anticancer Activity of Bis-(<i>N</i>-Glucosylated Triazolothiadiazolyl) Alkanes via Cyclocondensation Reaction Involving C–s and C–n Bond formation

<div><p>A series of bis-(4-amino-5-mercapto-1,2,4-triazol-3-yl) alkanes have been synthesized and were condensed with N-tetra-O-acetyl-β-D-glucopyranosyl isocyanodichloride to afford biologically active bis-[6-tetra-O-acetyl-β-D-glucopyranosylimino-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazol-4-yl] alkanes. The structures of the new glucosylated heterocyclic compounds have been established by IR, <sup>1</sup>H NMR, and <sup>13</sup>C NMR spectroscopy, and mass spectrometry analyses. Among the synthesized compounds, a few target compounds were screened for their in vitro</p><p>anticancer activity against two human cancer cell lines, viz. MCF-7 (Breast) and HEPG2 (Liver).</p></div>