Synthesis and anti-inflammatory activity of triazole-based macrocyclic amides through click chemistry

<p>Triazole-based macrocyclic amides <b>1–12</b> with amide group as the intrannular functionality has been synthesized through click chemistry. Triazole-based macrocyclic amides <b>1</b>–<b>12</b> show good anti-inflammatory activity even at low concentration (50 µg/mL) when compared to that of the reference drug prednisolone. BINOL-based chiral macrocyclic amides and pyridine-based macrocyclic amides show better anti-inflammatory activity than the other synthesized macrocyclic amides.</p>