jo4005074_si_002.pdf (5.03 MB)
Synthesis Studies on the Lomaiviticin A Aglycone Core: Development of a Divergent, Two-Directional Strategy
journal contribution
posted on 2013-05-03, 00:00 authored by Ken S. Feldman, Brandon R. SelfridgeThe
enantiomer of the bicyclic lomaiviticin aglycone A core was
prepared via a two-directional, divergent approach featuring (1) a
double Ireland Claisen rearrangement to establish key core bonds with
correct relative stereochemistry and (2) a double olefin metathesis
reaction to deliver both cyclohexene rings of the target.