Synthesis, Structure, and Antiproliferative Activity
of Ruthenium(II) Arene Complexes of Indenoisoquinoline Derivatives

Wambang, Nathalie; Schifano-Faux, Nadège; Martoriati, Alain; Henry, Natacha; Baldeyrou, Brigitte; Bal-Mahieu, Christine; Bousquet, Till; Pellegrini, Sylvain; Meignan, Samuel; Cailliau, Katia; Goossens, Jean-François; Bodart, Jean-François; T. Ndifon, Peter; Pélinski, Lydie

doi:10.1021/acs.organomet.6b00440.s001

om6b00440_si_001.pdf (671.66 kB)

Synthesis, Structure, and Antiproliferative Activity of Ruthenium(II) Arene Complexes of Indenoisoquinoline Derivatives

journal contribution

posted on 2016-08-19, 20:29 authored by Nathalie Wambang, Nadège Schifano-Faux, Alain Martoriati, Natacha Henry, Brigitte Baldeyrou, Christine Bal-Mahieu, Till Bousquet, Sylvain Pellegrini, Samuel Meignan, Katia Cailliau, Jean-François Goossens, Jean-François Bodart, Peter T. Ndifon, Lydie Pélinski

Novel ruthenium complexes of indenoisoquinoline derivatives were synthesized and characterized. The structure of the complex 9 was determined by single-crystal X-ray crystallography. Ruthenium complexes displayed strong DNA interactions. The cytotoxic activity of the complexes was tested against five cancer cell lines (MDA-MB-231, MCF-7, HEK-293, HT-29, and DU-145).