pcbi.1005862.g004.tif (221.35 kB)
Symmetry breaking in a fixed circle and in a free-boundary problem.
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posted on 2017-11-14, 18:47 authored by Masoud Nickaeen, Igor L. Novak, Stephanie Pulford, Aaron Rumack, Jamie Brandon, Boris M. Slepchenko, Alex Mogilner(a) Instability of a symmetric steady state of ZV model in a fixed circle: snapshots of dimensionless myosin density (pseudo-color) and actin velocities (arrows) at specified times t after myosin was slightly shifted left of center; computations were done for μtot = 1.5π and α = 0.5. (b) Transition to unidirectional motility in ZS model; dimensionless myosin concentration (pseudo-colors) and boundary velocities (arrows) are shown for the solution obtained with α = 1, v0 = 5, and μtot = 1.5π; the cell assumes steady unidirectional motility after t = 14 (S2 Movie).
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boundary counterscauses retractionconstant-strength viscous-like adhesionlamellipodial boundaryretraction shapescell boundarydimensionless parameter combinationsviscosity-adhesion lengthfree-boundary modelviscosity-adhesion lengthsmyosin-dependent contractilityactin protrusionmodel analysislamellipodial motilitymyosin transport equationsmyosin densitycentripetal actin flowmodel parameter spaceactin networkactin-myosin contractilitycontractionprotrusion causeActin protrusionmyosin redistributioncontractile mechanismfree-boundary modelsmotile cellmodels accountmotile behavior
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