Survival of neurons born in the developing rat dentate gyrus

Six day old rats were injected with the mitotic marker BrdU to label neurons born on that day in infancy. We then counted how many of those neurons were present 1,2,3,4,8 weeks later. We made the 1 week values 100% and then expressed the later timepoints as the fraction that survived. Our new data is the blue curve: developmentally-born neurons in the Long Evans rat. You can see that there is no change over time! This is very different from what you in the adult rat, where 40% of adult-born neurons die during by 4 weeks. In adult mice the process is similar to rats except even more neurons die. The adult rat data and the mouse data are taken from Snyder, 2009, J Neurosci.