Supported Palladium Nanoparticle Catalyzed α‑Alkylation of Ketones Using Alcohols as Alkylating Agents

Polymer stabilized palladium (Pd@PS) nanoparticles (NPs) catalyzed α-alkylation of acyclic, cyclic, and aliphatic ketones were performed with methanol, ethanol, and long chain alkyl and benzyl alcohols. The heterogeneous catalyst, Pd@PS, was found to be highly active for most challenging small chain alkyl alcohols such as methanol and ethanol in alkylation reaction following oxidation, condensation, and reduction approaches.