Supplementary Material from An efficient synthesis of 4<i>H</i>-pyrano quinolinone derivatives catalysed by a versatile organocatalyst tetra-<i>n</i>-butylammonium fluoride and their pharmacological screening
2017-11-17T12:35:21Z (GMT) by
A new series of indole-based pyranoquinoline derivatives <b>P<sub>1–24</sub></b> has been synthesized by a one-pot cyclocondensation reaction of 2-(4-substituted)phenyl-<i>N</i>-allyl-indole-3-carbaldehydes <b>1a–d</b>; active methylenes <b>2a–c</b>; and 4-hydroxy-1-substituted quinolin-2(1<i>H</i>)-one <b>3a–b</b> catalysed by an organocatalyst tetra-<i>n</i>-butylammonium fluoride (TBAF) in aqueous ethanol. The easy experimental procedure of the reaction leads to excellent yields of pyranoquinoline derivatives. All the compounds were screened against a representative panel of bacteria and fungi. Some of the compounds are found to be equipotent or more potent than standard drugs as evident from the structural activity relationship study.