Supplementary Material for: Introduction of Hypothermia for Neonates with Perinatal Asphyxia in the Netherlands and Flanders

<b><i>Background:</i></b> Therapeutic hypothermia was introduced in the Netherlands and Flanders, Belgium, in 2008. Since then, an increasing number of patients has been treated - up to 166 in 2010. Complications and outcome were registered in an online database. <b><i>Objectives:</i></b> The aim of this study was to analyse complications and outcome after implementation. <b><i>Methods:</i></b> Data were retrieved from an online database to which all centres had contributed. <b><i>Results:</i></b> In 3 years, 332 patients were treated. Excluding 24 patients with congenital abnormalities or metabolic disorders, mortality was 31.8%. Of the 210 survivors without congenital malformations, 21 had cerebral palsy, another 19 a developmental delay of more than 3 months at the age of at least 24 months, and 2 had severe hearing loss. The total adverse outcome, combining death and adverse neurodevelopment, in 308 patients without congenital malformations is 45.5%, which is similar to that of the large trials. <b><i>Conclusions:</i></b> The introduction of therapeutic hypothermia for neonates with perinatal asphyxia in the Netherlands and Flanders has been rapid and successful, with results similar to findings in the randomised controlled trials.