000329550_sm_Figure.pdf (82.68 kB)
Supplementary Material for: Importance of Toll-Like Receptor 9 in Host Defense against M1T1 Group A Streptococcus Infections
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posted on 2011-08-19, 00:00 authored by Zinkernagel A.S., Hruz P., Uchiyama S., von Köckritz-Blickwede M., Schuepbach R.A., Hayashi T., Carson D.A., Nizet V.Timely recognition and elimination of invasive group A Streptococcus (GAS) by innate immunity is crucial to control infection. The intracellular pattern recognition receptor Toll-like receptor 9 (TLR9) promotes macrophage hypoxia-inducible factor-1α levels, oxidative burst and nitric oxide production in response to GAS. TLR9 contributes to GAS clearance in vivo in both localized cutaneous and systemic infection models.
