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Supplementary Material for: Effects of Weight Loss with and without Exercise on Regional Body Fat Distribution in Postmenopausal Women
journal contribution
posted on 2017-06-08, 12:38 authored by Serra M.C., Blumenthal J.B., Addison O.R., Miller A.J., Goldberg A.P., Ryan A.S.Background/Aims: The purpose was to determine whether
lifestyle interventions have different effects on regional fat in women
with normal glucose tolerance vs. impaired glucose tolerance (NGT vs.
IGT). Methods: Changes in glucose metabolism (2-h oral
glucose-tolerance tests), android to gynoid fat mass ratio (dual energy
X-ray absorptiometry [DXA]), visceral to subcutaneous abdominal fat area
ratio (CT), and abdominal to gluteal subcutaneous fat cell weight (FCW;
adipose tissue biopsies) were determined in 60 overweight
postmenopausal women (45-80 years) following 6 months of weight loss
alone (WL; n = 28) or with aerobic exercise (AEX + WL; n = 32). Results: The interventions led to ∼8% decrease in weight, but only the AEX + WL group improved fitness (↑11% in VO2max) and reduced the android-to-gynoid fat mass ratio (↓5%; p
< 0.05). Both NGT and IGT groups reduced visceral and subcutaneous
abdominal fat areas and abdominal and gluteal FCWs, which related to
improvements in homeostatic model assessment (r = 0.34-0.42) and 2-h glucose (r = 0.34-0.35), respectively (p < 0.05). The decline in FCW was 2× greater in women with IGT following WL (p < 0.05). The ratios of abdominal-to-gluteal FCW did not change following either intervention. Conclusions:
The mechanisms by which WL with and without exercise impact regional
fat loss should be explored as reductions in abdominal fat area and
subcutaneous FCW appear to influence glucose metabolism. This is a work
of the U.S. Government and is not subject to copyright protection in
the United States. Foreign copyrights may apply.