Supplementary Material for: Effect of Orally Administered Potentized Capsaicin and Dihydrocapsaicin in Humans: A Homeopathic Pathogenetic Trial

Background: A homeopathic pathogenetic trial is a procedure to examine the disease-producing effect of any substance on humans. Capsaicin and dihydrocapsaicin are known as pain-producing agents. According to the homeopathic law of similars, any substance having the capacity to produce certain symptoms should also be able to treat them in return, when administered in small (potentized) dose. Methods: In a doubleblind, randomized placebo-controlled homeopathic pathogenetic trial with 22 volunteers, 15 received a combination of capsaicin and dihydrocapsaicin as a single remedy in 30c potency, while 7 received placebo. The volunteers' symptoms during 5 weeks were carefully noted as per protocol. The participants signed an informed consent, the study was approved by the ethics committee, and laboratory investigations were documented and safety measures adopted. Results: A preparation of orally administered ultra-high diluted capsaicin and dihydrocapsaicin unveiled qualitatively and quantitatively distinct symptoms, comparable with effects of the crude substance. Compared to placebo, the homeopathic preparation produced significant symptoms in healthy human volunteers. These findings can subsequently be used therapeutically. Conclusion: The administration of potentized capsaicin and dihydrocapsaicin combination produced symptoms of pain (and others) in healthy volunteers. This preparation can be applied therapeutically following a basic homeopathic principle. Further research to confirm the assumptions is warranted.